Septic shock (Prior learning)
- Definition
Septic shock is a subclass of distributive shock,
a condition in which abnormal distribution of blood flow
in the smallest blood vessels results in inadequate blood supply
to the body tissues, resulting in ischemia and organ dysfunction.
Septic shock refers specifically to distributive shock due to
sepsis as a result of infection.
Septic shock may be defined as sepsis-induced low blood pressure
that persists despite treatment with intravenous fluids.
Low blood pressure reduces tissue perfusion pressure,
causing the tissue hypoxia that is characteristic of shock.
Cytokines released in a large scale inflammatory response result
in massive vasodilation, increased capillary permeability,
decreased systemic vascular resistance, and low blood pressure.
Finally, in an attempt to offset decreased blood pressure,
ventricular dilatation and myocardial dysfunction occur.
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