Septic shock (Prior learning)

- Definition

Septic shock is a subclass of distributive shock, 

a condition in which abnormal distribution of blood flow 

in the smallest blood vessels results in inadequate blood supply 

to the body tissues, resulting in ischemia and organ dysfunction. 

Septic shock refers specifically to distributive shock due to 

sepsis as a result of infection.

Septic shock may be defined as sepsis-induced low blood pressure 

that persists despite treatment with intravenous fluids. 

Low blood pressure reduces tissue perfusion pressure, 

causing the tissue hypoxia that is characteristic of shock. 

Cytokines released in a large scale inflammatory response result 

in massive vasodilation, increased capillary permeability, 

decreased systemic vascular resistance, and low blood pressure. 

Finally, in an attempt to offset decreased blood pressure, 

ventricular dilatation and myocardial dysfunction occur.

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